FORM 4 ☐ Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * Schwartzberg Gil	2. Issuer Name and Ticker or Trading Symbol LIXTE BIOTECHNOLOGY HOLDINGS, INC. [ LIXT.OB ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                    __X__ 10% Owner _____ Officer (give title below)    _____ Other (specify below)
(Last)          (First)          (Middle) 5500 MILITARY TRAIL, SUITE 22	3. Date of Earliest Transaction (MM/DD/YYYY) 12/7/2018
(Street) JUPITER, FL 33458	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person
(City)        (State)        (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	12/7/2018		P		1,040,000	A	$0.5 (1)	1,895,068	D
Common Stock	12/7/2018		J(2)		150,000 (2)	A	$0	2,045,068	D
Common Stock	12/7/2018		G		600,000	D	$0	1,066,356	I	By Gil & Debbie Schwartzberg Family Trust, Gil Schwartzberg Separate Property
Common Stock								63,811 (3)	I	By Continuum Partners, L.P.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Warrants to Purchase Common Stock	$1	12/7/2018		P		1,040,000		12/7/2018	11/30/2022	Common Stock	1,040,000	$0.5	1,540,000	D
Warrants to Purchase Common Stock	$1	12/7/2018		G			1,040,000	12/7/2018	11/30/2022	Common Stock	1,040,000	$0	0	D

Explanation of Responses:
(1)	The reporting person acquired 1,040,000 Units, each Unit consisting of one share of Common Stock and a four year warrant at an exercise price of $1.00 per share. The purchase price for a Unit was $0.50.
(2)	Represents shares acquired by the reporting person pursuant to enforcement of a judgment.
(3)	Represents the reporting person's proportionate interest in Continuum Partners, L.P. which owns 638,115 shares of the issuer's common stock.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Schwartzberg Gil 5500 MILITARY TRAIL, SUITE 22 JUPITER, FL 33458		X

Signatures
/s/ Gil Schwartzberg		12/11/2018
**Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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