The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

  UNITED STATES SECURITIES AND EXCHANGE COMMISSION OMB APPROVAL
 Washington, D.C. 20549
FORM 13F
OMB Number:   3235-0006
Estimated average burden
hours per response:       23.8


FORM 13F COVER PAGE


Report for the Calendar Year or Quarter Ended:
06-30-2025
 
Check here if Amendment:      Amendment Number:
 
This Amendment (Check only one.):    is a restatement.
     adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:Merck & Co., Inc. 
Address:126 EAST LINCOLN AVENUE 
 P.O. BOX 2000 
 RAHWAY NJ 07065 

Form 13F File Number:  028-25193 
CRD Number (if applicable):   
SEC File Number (if applicable):   


The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:

Name:Kelly Grez 
Title:Corporate Secretary 
Phone: 908-740-4000 

Signature, Place, and Date of Signing:

/s/ Kelly Grez Rahway,  NEW JERSEY 08-13-2025 
[Signature][City, State][Date]

Do you wish to provide information pursuant to Special Instruction 5?        Yes      X  No

Report Type (Check only one.):

X  13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)

     13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)

     13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
Form 13F Information table Entry Total:13 
Form 13F Information table Value Total:215,600,331 
 (round to nearest dollar)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F number(s) of all institutional investement managers with respect to which this report is filed, other than the manager filing this report.

   No.NameForm 13F File NumberCRD No. (if applicable)SEC File No. (if applicable)CIK
MERCK SHARP & DOHME LLC    0000064978 

FORM 13F INFORMATION TABLE

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
NAME OF ISSUER TITLE OF CLASS CUSIPFIGI VALUE
(round to nearest dollar)
SHRS OR
PRN AMT
SH /
PRN
PUT /
CALL
INVESTMENT
DISCRETION
OTHER
MANAGER
VOTING AUTHORITY
SOLESHAREDNONE
ALECTOR INCCOM014442107-4,964,0073,545,719SH-DFND-03,545,7190
CARISMA THERAPEUTICS INCCOM14216R101-576,9211,473,240SH-DFND-01,473,2400
ENTRADA THERAPEUTICS INCCOM29384C908-11,691,2411,739,768SH-DFND-01,739,7680
EVAXION BIOTECH A/SSPONSORED ADS29970R204-2,974,6091,214,126SH-DFND-01,214,1260
KYMERA THERAPEUTICS INCCOM501575104-33,697,281772,165SH-DFND-0772,1650
LAVA THERAPEUTICS NVSHSN51517105-1,517,1351,149,345SH-DFND-01,149,3450
MODERNA INCCOM60770K107-63,682,9622,308,190SH-DFND102,308,1900
NEUPHORIA THERAPEUTICS INCCOM64136E102-71,19210,027SH-DFND1010,0270
PERSONALIS INCCOM71535D106-92,134,82614,044,943SH-DFND1014,044,9430
SUTRO BIOPHARMA INCCOM869367102-1,944,3132,723,509SH-DFND102,723,5090
TUHURA BIOSCIENCESCOM898920103-31,10913,950SH-DFND1013,9500
VIRIDIAN THERAPEUTICS INCCOM92790C104-1,305,92893,414SH-DFND-093,4140
XILIO THERAPEUTICS INCCOM98422T100-1,008,8071,483,758SH-DFND-01,483,7580